论文部分内容阅读
为了通过动物模型验证胃肠透析液(GJD)对流行性出血热(EHF)的治疗安全度和效果,特进行如下两个方面的试验:1.急性毒性试验:对健康成年家兔和小鼠,采用临床用药量的5倍浓缩胃肠透析液,灌胃给药,连续观察一周,均未见明显毒性反应。2.对家兔急性肾衰模型的影响:用0.1％升汞引起家兔的急性肾衰模型仍用前述5倍浓缩液,按120～160ml/kg灌胃,测定透析前后的Cr和BUN值,经配对t检验并与对照组比较,证实有一定的治疗效果(P<0.01)。上述实验结果表明:胃肠透析疗法对流行性出血热的治疗是安全而有效的。
In order to verify the safety and efficacy of Gastrointestinal Dialysate (GJD) for Epidemic Hemorrhagic Fever (EHF) through animal models, the following two aspects of the test are specifically performed: 1. Acute toxicity test: for healthy adult rabbits and mice The use of clinically used 5 times concentrated gastrointestinal dialysate, intragastric administration, continuous observation for a week, no significant toxicity. 2. Effect on acute renal failure model in rabbits: The acute renal failure model induced by 0.1% Hg in rabbits was still intragastrically administered at 120-160 ml/kg using the aforementioned 5-fold concentrate, and the Cr and BUN values before and after dialysis were measured. The paired t-test and comparison with the control group confirmed a certain therapeutic effect (P<0.01). The above experimental results show that: Gastrointestinal dialysis therapy is safe and effective for the treatment of epidemic hemorrhagic fever.