目的:观察新型气体信号分子二氧化硫(SO2)对老年ALI大鼠肺泡巨噬细胞分泌和吞噬功能的影响。方法:将48只20~24月龄,体重758±47 g的老年大鼠随机分为3组:对照组、ALI组和SO2治疗组。SO2治疗组和ALI大鼠气管内滴注脂多糖(LPS,每只200μg)后,分别立即腹腔注射SO2供体Na2SO3(0.54 mmol/kg)/NaH SO3(0.18 mmol/kg)和等体积生理盐水。对 Objective: To observe the effect of a novel gas signaling molecule SO2 on the secretion and phagocytosis of alveolar macrophages in aged ALI rats. Methods: Forty-eight aged rats aged 20 to 24 months with a body weight of 758 ± 47 g were randomly divided into three groups: control group, ALI group and SO2 treatment group. SO2 treatment group and ALI rats were intratracheally instilled with SO2 donor Na2SO3 (0.54 mmol / kg) / NaH SO3 (0.18 mmol / kg) and an equal volume of normal saline . Correct