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目的:探讨寒热证型与甲状腺激素、炎性细胞因子的关系。方法:取清洁级Wistar大鼠60只,随机取20只为正常对照组,另40只各取20只分别制备热证及寒证模型,造模成功后设为热证模型组和寒证模型组,比较3组大鼠血清甲状腺激素及炎性细胞因子水平变化情况。结果:实验后血清三碘甲状腺氨酸(T3)、四碘甲状腺氨酸(T4)、游离三碘甲腺原氨酸(FT3)、游离四碘甲腺原氨酸(FT4)、肿瘤坏死因子α(TNF-α)及白细胞介素-8(IL-8)6项指标组间比较,差异均有统计学意义(P=0.000),且热证模型组>正常对照组>寒证模型组。结论:寒热证模型组的血清甲状腺激素及炎性细胞因子水平不同,内分泌激素水平及炎性细胞因子水平的高低均是形成寒热证的主要病理生理基础。
Objective: To investigate the relationship between cold and heat syndrome and thyroid hormone and inflammatory cytokines. Methods: Totally 60 Wistar rats were randomly divided into normal control group (n = 20) and normal control group (n = 20) The levels of serum thyroid hormones and inflammatory cytokines in the three groups were compared. Results: Serum levels of triiodothyronine (T3), tetraiodothyronine (T4), free triiodothyronine (FT3), free tetraiodothyronine (FT4), tumor necrosis factor α (TNF-α) and interleukin-8 (IL-8) were compared between the two groups, the difference was statistically significant (P = 0.000), and heat syndrome model group> normal control group> . Conclusion: The levels of serum thyroid hormones and inflammatory cytokines in cold-heat syndrome model group are different. The levels of endocrine hormones and inflammatory cytokines are the main pathophysiological basis for the formation of cold-heat syndrome.