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目的:探讨胎儿期开始应用维生素K1预防早产儿颅内出血的效果。方法:观察组选择具有早产高危因素的孕妇50例,于分娩前应用维生素K110 m g肌内注射或静脉注射,连用2~5 d;对照组为同期住院具有早产高危因素分娩前未用任何预防措施的孕妇65例。结果:观察组颅内出血的发生率为30%,对照组颅内出血的发生率为68%,两组经统计学处理差异有统计学意义。结论:提示胎儿期开始使用维生素K1预防早产儿颅内出血效果良好,方法简便,值得推广。
Objective: To investigate the effect of vitamin K1 on the prevention of intracranial hemorrhage in preterm infants during fetal period. Methods: In the observation group, 50 pregnant women with risk factors for preterm birth were selected and intravitreally administered with vitamin K110 mg intramuscularly or intravenously before delivery for 2-5 days. The control group was hospitalized with the same risk of preterm birth without preventive measures Of 65 pregnant women. Results: The incidence of intracranial hemorrhage was 30% in the observation group and 68% in the control group, and the difference was statistically significant between the two groups. Conclusion: It is suggested that vitamin K1 can be used to prevent intracranial hemorrhage in preterm infants with good effect and its method is simple and worth popularizing.