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目的:了解黄连对新生儿黄疸发病的影响作用,为黄连的安全性用药提供依据。方法:回顾性调查412例新生儿黄疸患儿的临床资料,用Cox模型对其发病的影响因素进行单因素和多因素分析,建立预测方程,根据回归系数、相对危险度、wald值比较评价黄连对新生儿黄疸发病的影响作用。结果:单因素Cox模型分析显示影响新生儿黄疸发病的主要因素有5项,多因素Cox模型分析证明该5项也是影响新生儿黄疸发病的独立因素,按作用大小排列分别为年龄、应用黄连、民族、G6PD缺乏和剖宫产。其中,应用黄连的回归系数-0.259,相对危险度0.772,wald值6.832,是属于对新生儿黄疸发病具有降低危险度的保护因子。根据回归系数建立的影响新生儿黄疸发病的预测方程h(t,x)=h0(t)exp(-0.022x2-0.494x3+0.344x+0.226x-0.259x)。结论:黄连是影响新生儿黄疸发病的重要因素之一;黄连对新生儿黄疸的发病具有保护作用。
Objective: To understand the impact of Coptis on the incidence of neonatal jaundice, to provide a basis for the safety of Coptis. Methods: The clinical data of 412 neonates with jaundice were retrospectively investigated. Cox regression model was used to analyze the influencing factors of the incidence of jaundice. Single factor and multivariate analysis were used to establish the predictive equation. Based on the regression coefficient, relative risk and wald value, Impact on the incidence of neonatal jaundice. Results: Univariate Cox model analysis showed that there were 5 main factors influencing the incidence of jaundice in neonates. Cox regression analysis showed that these 5 items were also independent factors affecting neonatal jaundice. According to the effect size, Ethnicity, G6PD deficiency and cesarean section. Among them, the application of Coptis regression coefficient -0.259, the relative risk of 0.772, wald value of 6.832, belong to the neonatal jaundice with risk reduction protection factor. The predictive equation h (t, x) = h0 (t) exp (-0.022x2-0.494x3 + 0.344x + 0.226x-0.259x) that affects the incidence of neonatal jaundice based on regression coefficients was established. Conclusion: Coptis chinensis is one of the important factors that affect the incidence of neonatal jaundice. Coptis chinensis has a protective effect on the incidence of neonatal jaundice.