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目的 :评价不同剂量AT1受体拮抗剂valsartan单用和与benazepril联合应用对SHR的降压疗效、逆转心肌肥厚作用和对RAAS、内洋地黄素水平的影响。方法 :30只 14周龄雄性SHR随机分成空白对照组、benazepril组、小剂量valsartan组、大剂量valsartan组和小剂量valsartan与benazepril联用组 ,另设WKY正常对照组 ,分别给予生理盐水、benazepril1mg·kg-1、valsartan 8mg·kg-1、valsartan 2 4mg·kg-1、valsartan 8mg·kg-1+benazepril1mg·kg-1,每日 1次灌胃给药 ,持续 8周。结果 :药物干预各组SHR动脉收缩压 (SBP)水平明显下降 ,尤以大剂量valsartan组和联合用药组SBP下降最显著 ;药物干预各组血浆和心肌组织肾素活性均明显升高 ;benazepril组和小剂量valsartan与benazepril组血浆和心肌组织AngⅡ水平降低 ;大、小剂量valsartan组血浆和心肌组织AngⅡ水平均明显升高 ,valsartan剂量越大 ,血浆和心肌组织AngⅡ水平升高越明显 ;随SBP水平的降低 ,心肌组织Na+ -K+ -ATP酶活性明显升高 ,而内洋地黄素水平则明显下降 ;药物干预各组LVM/BW、TDM均明显减低 ,尤以联合用药组改变最为显著。结论 :不同剂量AT1拮抗剂valsartan和benazepril单用或联用均有明显的降低SHR的SBP作用 ,能明显抑制左室肥厚进展 ;联合用药效果最
OBJECTIVE: To evaluate the antihypertensive efficacy of valsartan alone or in combination with benazepril at different doses, and to reverse the effects of cardiac hypertrophy and RAAS and endoxin on rehmannia. Methods: Thirty male 14-week-old SHRs were randomly divided into blank control group, benazepril group, low-dose valsartan group, high-dose valsartan group and low-dose valsartan combined with benazepril. Normal WKY control group was given saline, benazepril1mg · Valsartan 8 mg · kg -1, valsartan 2 4 mg · kg -1, valsartan 8 mg · kg -1 + benazepril 1 mg · kg -1, administered orally once per day for 8 weeks. Results: The SBP of SHR decreased significantly in each group, especially in the high dose valsartan group and the combination group. The decrease of SBP in the plasma and myocardial tissue of the drug intervention group was significantly increased. The benazepril group And low dose of valsartan and benazepril group plasma and myocardial Ang Ang levels decreased; large and small dose valsartan group plasma and myocardial Ang Ⅱ levels were significantly increased valsartan dose, the plasma and myocardial Ang Ang levels were more obvious; with SBP The levels of Na + -K + -ATPase in myocardium were significantly increased, while the levels of endoxin in the myocardium were significantly decreased. The LVM / BW and TDM in the intervention group were significantly decreased, especially in the combination group. CONCLUSIONS: Various doses of AT1 antagonist valsartan and benazepril alone or in combination have significantly reduced the SBP effect of SHR, which can significantly inhibit the progression of left ventricular hypertrophy. The combination effect