论文部分内容阅读
目的:研究CD147及MMP-14在大肠癌组织中的表达,分析两者在大肠癌组织中临床病理特征及表达之间的相关性。方法:选取2012年1月到2014年1月邵阳市中心医院胃肠外科收治的经病理诊断的大肠癌患者50例,采用免疫组织化学方法检测50例大肠癌患者癌组织及正常组织中CD147、MMP-14的表达情况,分析两者的表达水平与临床病理特征参数之间的相关性,用Pearson法分析两者表达之间是否相关。结果:大肠癌组织中CD147、MMP-14阳性表达率分别为80%、56%显著高于正常大肠组织24%、16%(P<0.05);大肠癌组织中CD147表达与发病年龄、性别、位置、肿瘤大小、组织学分化程度无统计学差异,与淋巴结转移及Duck分期有统计学差异;MMP-14表达与发病年龄、性别、位置、肿瘤大小无统计学差异,与组织学分化程度、淋巴结转移及Duck分期有统计学差异;大肠癌组织中CD147、MMP-14两者表达呈正相关r=0.363(P<0.05)结论:大肠癌组织中CD147、MMP-14阳性表达显著高于大肠正常组织,与淋巴结转移及Duck分期有关(P<0.05),两者具有相关性,同时高表达提示肿瘤具有更高的侵袭转移能力。
OBJECTIVE: To study the expression of CD147 and MMP-14 in colorectal carcinoma, and to analyze the correlation between them in clinicopathological features and expression in colorectal cancer. Methods: Fifty patients with pathologically diagnosed colorectal cancer admitted to Shaoyang Central Hospital from January 2012 to January 2014 were enrolled in this study. Immunohistochemistry was used to detect the expression of CD147 in 50 cases of colorectal cancer and normal tissues, MMP-14 expression, analyze the correlation between the expression level and the clinicopathological parameters, and analyze whether Pearson correlation between the two expression. Results: The positive rates of CD147 and MMP-14 in colorectal cancer tissues were 80% and 56% respectively, which were significantly higher than those in normal colorectal tissues (24% and 16%, respectively) (P <0.05) There was no significant difference in tumor size, location, tumor size, histological differentiation, lymph node metastasis and Duck staging. There was no significant difference in the expression of MMP-14 between age, sex, location and tumor size, histological grade, (P <0.05) .Conclusion: The positive expression of CD147 and MMP-14 in colorectal carcinoma was significantly higher than that in the large intestine (P <0.05) .Conclusion: The positive expression of CD147 and MMP- (P <0.05). There was a correlation between them and lymph node metastasis and Duck stage (P <0.05), and high expression suggested that the tumor had higher invasion and metastasis.