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目的:观察骨疏颗粒对去卵巢骨质疏松大鼠骨代谢的影响,探讨骨疏颗粒防治骨质疏松的可能作用机制。方法:将3月龄SPF级SD雌性大鼠40只,随机分为假手术组、模型组、补佳乐(BJL)(戊酸雌二醇)组及骨疏颗粒(GSKL)组。假手术组只行假手术,其余3组去大鼠双侧卵巢复制绝经后骨质疏松症的模型。术后第4天开始分别给予对应药物灌胃,12周后检测血清钙、血清磷、尿钙与尿肌酐比值,称取子宫重量,计算子宫指数。结果:与假手术组比较,模型组尿钙与尿肌酐比值显著增加(P<0.05);与模型组比较,BJL组及GSKL组尿钙与尿肌酐比值显著降低(P<0.05)。各组血钙、血磷无明显变化(P>0.05)。与假手术组比较,模型组子宫指数显著降低(P<0.05);与模型组比较,BJL组子宫指数明显增加(P<0.05),GSKL组子宫指数略增加,差异无统计学意义(P>0.05)。结论:骨疏颗粒能降低骨吸收,桔抗骨质疏松。
Objective: To observe the effect of Gushu granule on bone metabolism in ovariectomized rats and to explore the possible mechanism of Gushu granules in preventing and treating osteoporosis. Methods: Forty SPF SD female rats of 3 months old were randomly divided into sham operation group, model group, BJL (estradiol valerate) group and GSKL group. Sham operation group only sham operation, and the remaining three groups to bilateral bilateral ovarian model of postmenopausal osteoporosis. At the 4th day after operation, the corresponding drugs were given respectively. After 12 weeks, the serum calcium, serum phosphorus, urinary calcium and urinary creatinine were measured. The uterine weight was weighed and the uterine index was calculated. Results: Compared with the sham operation group, the ratio of urinary calcium and urinary creatinine in the model group increased significantly (P <0.05). Compared with the model group, the ratio of urinary calcium to urinary creatinine in BJL group and GSKL group decreased significantly (P <0.05). Each group of serum calcium, phosphorus did not change significantly (P> 0.05). Compared with the sham operation group, the uterine index in the model group decreased significantly (P <0.05). Compared with the model group, the uterine index increased significantly (P <0.05) in the BJL group and slightly increased in the GSKL group (P> 0.05). Conclusion: Gu Shu granules can reduce bone resorption, orange anti-osteoporosis.