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目的为了解上海市虹口区育龄期妇女风疹抗体水平,最终为完善风疹免疫策略,控制风疹、预防先天性风疹综合征(CRS)提供科学依据。方法随机选择20岁以上育龄期妇女,其中本区186人和外来178人,采血后用定量酶联免疫吸附试验法进行风疹IgG抗体水平检测,并进行卫生统计分析。结果总体风疹抗体阳性率90.80%,抗体平均水平为123.61 IU/ml,各年龄组方差分析,F=16.32,P=0.000,差异有统计学意义,随年龄增长,风疹抗体水平显著下降。其中本市育龄妇女风疹抗体阳性率为90.57%、抗体平均水平为114.65 IU/ml;外来育龄妇女风疹抗体阳性率为91.02%,外来妇女风疹抗体平均水平132.14 IU/ml。结论为达到防制风疹目标,做好优生优育,预防CRS应对育龄期妇女在生育期之前加强接种风疹疫苗(或含有风疹疫苗的联合疫苗),提高育龄妇女风疹抗体水平。
Objective To understand the level of rubella antibody in the women of childbearing age in Hongkou District, Shanghai, and to provide the scientific basis for improving the rubella immunization strategy, controlling rubella and preventing congenital rubella syndrome (CRS). Methods A total of 186 women of childbearing age above 20 years old were randomly selected, including 186 in this district and 178 from outside. Blood samples were collected for the detection of rubella IgG antibody by quantitative enzyme-linked immunosorbent assay (ELISA), and the health statistics were analyzed. Results The overall rubella antibody positive rate was 90.80%. The average level of antibody was 123.61 IU / ml. The ANOVA was F = 16.32, P = 0.000 in all age groups. The difference was statistically significant. The level of rubella antibody decreased significantly with age. The prevalence of rubella antibody was 90.57% and the average antibody level was 114.65 IU / ml. The positive rate of rubella antibody in foreign women of child-bearing age was 91.02% and the average level of rubella antibody in foreign women was 132.14 IU / ml. Conclusion In order to achieve the goal of controlling rubella, good prenatal and postnatal care should be done to prevent CRS. In the women of childbearing age, rubella vaccine (or combined vaccine containing rubella vaccine) should be strengthened before the childbearing age to raise the level of rubella antibody in women of childbearing age.