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目的:分析β-内酰胺类抗生素不良反应的特点,促进合理用药。方法:对重庆市ADR监测中心收到的β-内酰胺类抗菌药物ADR病例报告进行分析。结果:133例β-内酰胺类抗生素ADR病例报告中涉及26种β-内酰胺类抗菌药物,主要为头孢曲松钠(37例),青霉素(20例)和头孢噻肟钠(12例)。A型不良反应18例,B型不良反应115例,不良反应以过敏反应居多(98例)。反应程度绝大多数为轻、中度反应,重度反应15例,其中死亡1例。结论:应合理使用β-内酰胺类抗生素,避免和减少不良反应的发生。
Objective: To analyze the characteristics of adverse reactions of β-lactam antibiotics and promote the rational use of drugs. Methods: ADR surveillance center in Chongqing received β-lactam antibiotics ADR case reports were analyzed. Results: A total of 26 β-lactam antibiotics were reported in 133 cases of β-lactam antibiotics, including ceftriaxone sodium (37 cases), penicillin (20 cases) and cefotaxime sodium (12 cases) . A type of adverse reactions in 18 cases, B type of adverse reactions in 115 cases, the majority of adverse reactions to allergic reactions (98 cases). The vast majority of response to light, moderate reaction, severe reaction in 15 cases, of which 1 case of death. Conclusion: β-lactam antibiotics should be used rationally to avoid and reduce adverse reactions.