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目的通过动态分析,了解和掌握艾滋病(AIDS)患者和艾滋病病毒(HIV)感染者血液中CD4变化趋势和规律特点,为是否给予CD4检测提供科学依据。方法 CD4检测用单平台一步法,数据用统计学方法处理。结果 HIV感染者大多数CD4逐步下降,治疗后开始回升,治疗3个月后速度最快,与治疗月相比,差异有统计学意义(P<0.01)。其后速度减缓,差别不显著。在未治疗者中,有28.1%的患者CD4低于200个/μ1。监测期间的死亡者,多为本人未及时接受救治所致。结论 HIV-1抗体阳性确认后,治疗前和用新方案治疗3个月,出现临床危相者都应列入CD4监测对象。检测工作安排定期检测和应急检测较为完满。CD4检测设到地方级实验室更有利于工作。
Objective To understand and grasp the trend of CD4 in the blood of AIDS patients and HIV infected persons by dynamic analysis, and to provide a scientific basis for CD4 test. Methods Single-platform CD4 assay was performed by one-step method and the data was processed by statistical methods. Results The majority of HIV-infected patients were gradually decreased CD4 levels, after treatment began to rise, the fastest 3 months after treatment, compared with the treatment month, the difference was statistically significant (P <0.01). Slower thereafter, the difference is not significant. Among untreated patients, 28.1% of patients had CD4 below 200 / μl. During the monitoring of death, mostly because I did not receive timely rescue treatment. Conclusion HIV-1 antibody positive confirmation, before treatment and with new regimen for 3 months, clinical critically ill should be included in the monitoring of CD4. Detection of work arrangements for regular testing and emergency detection is more complete. CD4 test set to local level laboratory is more conducive to work.