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例1:男,36岁,因发热5天而服用萘普生片(西南制药二厂生产,批号861201,每片200mg)每次1片,1日3次,服用8片后周围血细胞由5×10~9/L降至2×10~9/L,并发现幼稚粒细胞3%,幼稚细胞样变异淋巴28%,95%的粒中性细胞有粗大中毒颗粒。停药后白细胞逐渐回升,第7天7×10~9/L,但中性粒细胞仍有半数有中毒颗粒,少数有空泡变性。发热12天后热退,复查血象白细胞数及形态均正常,最后诊断:萘普生过敏。
Example 1: Male, 36 years old, taking naproxen tablets (produced by Southwest Pharmaceutical Factory No. 2, batch No. 861201, each tablet 200mg) for 1 day after heating for 5 days, 3 times on 1st and after taking 8 tablets, the peripheral blood cells from 5 × 10 ~ 9 / L to 2 × 10 ~ 9 / L, and found that 3% of juvenile neutrophils, immature cell-like lymphoid mutation 28%, 95% of granular neutrophils have coarse poisoning particles. After stopping the leukocytes gradually rose, 7 days 7 × 10 ~ 9 / L, but there are still half of neutrophils poisoning particles, a small number of vacuolar degeneration. Heat back after 12 days fever, blood white blood cell count and morphology were normal, the final diagnosis: naproxen allergy.