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组织学检查常作为肿瘤诊断的依据。但常常因活检不能发现肿瘤而失败。近来发现生物化学方法能发现早期癌症。肝细胞癌组织化学表型的异常已有报导。这些报导指出肝细胞癌有三个异常特征,即γ-谷酰转酞酶活性增高,5-三磷酸腺苷酶活性、葡萄糖6-磷酸酶活性降低。此外,肺吸出物中碱性磷酸酶(AKP)水平的测定也被用来评价阻塞性肺疾的细胞损
Histological examination is often used as a basis for tumor diagnosis. But often because of biopsy can not find the tumor and fail. Recently discovered biochemical methods can detect early cancer. Abnormalities in the histochemical phenotype of hepatocellular carcinoma have been reported. These reports suggest that there are three abnormal characteristics of hepatocellular carcinoma, namely, increased activity of γ-glutamyltransferase, adenosine-5-ATPase activity, and decreased glucose-6-phosphatase activity. In addition, the determination of alkaline phosphatase (AKP) levels in lung aspirate is also used to evaluate the cytopathicity of obstructive lung disease.