先天性无眼球为一罕见的先天畸形,国内先后有过四篇报道,均为婴儿。笔者所遇一家两姐妹三只眼眼球缺如,均为成人,现报道如下。例1:胡××,女,19岁。出生时即眼凹塌陷,“眼珠”缺如。患者系首胎足月顺产。体检:智力发育相当于学龄儿童,生长发育稍迟缓,身高体重稍落后于同年龄女孩,性发育无异常。五官除双眼外均发育正常。心肺正常,肝脾未扪及,脊椎 Congenital absence of the eye as a rare congenital malformations, there have been four reports, are infants. I encountered a two sisters three eyes missing eyes, are adults, are reported below. Example 1: Hu × ×, female, 19 years old. Sagittal collapse collapse at birth, “eyes” missing. The first fetus of patients with full-term birth. Physical examination: intellectual development is equivalent to school-age children, growth and development of a slow, height and weight slightly behind the same age girls, sexual development without exception. In addition to facial features both eyes are normal. Cardiopulmonary normal, liver and spleen not palpable, spine