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应用PCR-RFLP技术及基因测序方法检测大连地区汉族人2型DM患者[动脉粥样硬化(AS)组110例,非AS组120例]线粒体DNA(mtDNA)16189位点变异。As组mtDNA 16189T→C变异率高于非AS组(35．5％vs20．0％,P<0．01)。mtDNA 16189 T→C变异组HOMA-IR和HbAIC高于非变异组(P <0．05)。因此,mtDNA 16189 T→C变异可能与胰岛素抵抗、较高血糖水平和2型DM早期AS相关。
The polymorphism of mitochondrial DNA (mtDNA) 16189 in 110 patients with atherosclerosis (AS) and 120 patients with non-AS in Han type 2 DM patients in Dalian area was detected by PCR-RFLP and gene sequencing. The mutation rate of mtDNA 16189T → C in As group was higher than that in non-AS group (35.5% vs20.0%, P <0.01). HOMA-IR and HbAIC in mtDNA 16189 T → C mutation group were higher than those in non-mutation group (P <0.05). Therefore, the mutation of mtDNA 16189 T → C may be related to insulin resistance, high blood glucose level and type 2 DM early AS.