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目的探讨妊娠期糖尿病患者血清同型半胱氨酸水平(homocysteine,Hcy)与脂联素水平(adiponectin,APN)的关系。方法选择2012年1月-12月就诊于河北省唐山市开滦总医院的妊娠期糖尿病(gestational diabetes mellitus,GDM)患者52例为病例组,同期正常妊娠妇女52例作为对照组。分析比较两组间Hcy和APN水平,同时分析Hcy和APN之间的相关性。结果病例组Hcy(14.5±4.8)μmol/L、血糖(8.2±3.1)μmol/L水平均显著高于对照组(8.7±3.5)mmol/L、(5.6±1.4)mmol/L,差异均有统计学意义(P<0.001);病例组APN(7.8±2.3)mg/L、(17.2±4.4)mg/L水平显著低于对照组,差异有统计学意义(P<0.001)。血糖水平与Hcy和APN均具有中度相关关系。结论妊娠糖尿病患者Hcy水平高于正常妊娠者,APN水平低于正常妊娠者;Hcy水平与APN水平具有中度负相关关系。
Objective To investigate the relationship between serum homocysteine (Hcy) and adiponectin (APN) in patients with gestational diabetes. Methods 52 cases of gestational diabetes (gestational diabetes mellitus, GDM) visited from January 2012 to December 2012 in Kailuan General Hospital of Tangshan City, Hebei Province were selected as the case group, and 52 cases of normal pregnant women as control group. The levels of Hcy and APN were compared between the two groups, and the correlation between Hcy and APN was analyzed. Results The levels of Hcy (14.5 ± 4.8) μmol / L and blood glucose (8.2 ± 3.1) μmol / L were significantly higher than those of the control group (8.7 ± 3.5) mmol / L and (P <0.001). The levels of APN (7.8 ± 2.3) mg / L and (17.2 ± 4.4) mg / L in the case group were significantly lower than those in the control group (P <0.001). There was a moderate correlation between blood glucose levels and Hcy and APN. Conclusion The Hcy level in gestational diabetes mellitus patients is higher than that in normal pregnancy, and the APN level is lower than that in normal pregnancy. The Hcy level has a moderate negative correlation with APN level.