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心房颤动是临床上最常见的心律失常之一,抗心律失常药物因效果不佳且不良反应多,使其在心房颤动的防治中应用有限。血管紧张素Ⅱ通过促进心房纤维化,缩短心房有效不应期,延长房室传导,诱导细胞内Ca2+超负荷及炎症反应等,促进心房的电重构及组织重构,从而在心房颤动的发生和维持中起积极作用。越来越多的研究表明血管紧张素Ⅱ受体拮抗剂在心房颤动的防治中具有广泛作用。
Atrial fibrillation is one of the most common cardiac arrhythmias in clinical practice. Antiarrhythmic drugs are often used in the prevention and treatment of atrial fibrillation due to poor efficacy and adverse reactions. Angiotensin Ⅱ promotes the atrial electrical remodeling and tissue remodeling through the promotion of atrial fibrosis, shortening the effective refractory period of atria, prolonging atrioventricular conduction, inducing intracellular Ca2 + overload and inflammatory reaction, And maintain a positive role. More and more studies have shown that angiotensin Ⅱ receptor antagonists have a broad role in the prevention and treatment of atrial fibrillation.