论文部分内容阅读
目的通过对比添加谷氨酰胺的肠内营养支持治疗,探讨其对脓毒症患者免疫功能的影响。方法收集2010～2011年确诊脓毒症并添加肠内营养治疗患者96例,其中给予谷氨酰胺强化(干预组)的48例,未给予谷氨酰胺(对照组)的48例,分别于入院第1、10d,测定两组患者淋巴细胞计数、IgG、IgA、IgM、CD4+、CD4+/CD8+值,并进行统计学分析。结果两组患者年龄、APACHEⅡ之间无差异性,治疗前两组淋巴细胞计数、IgG、IgA、IgM、CD4+、CD4+/CD8+无差异性,治疗10d后干预组的淋巴细胞(0.604±0.123)、IgG(11.71±1.71)、IgA(2.33±0.18)、CD4(36.11±2.151)增高,与对照组比较均有统计学意义(P<0.01)。结论谷氨酰胺强化的肠内营养治疗能提高脓毒症患者的免疫功能,改善脓毒症患者的预后。
Objective To compare the effects of glutamine supplementation with enteral nutrition on the immune function of patients with sepsis. Methods Ninety-six patients with confirmed sepsis and enteral nutrition were collected from 2010 to 2011. Forty-eight patients with glutamine-enhanced (intervention group) and 48 patients without glutamine (control group) were enrolled in hospital On the 1st and 10th day, the counts of lymphocytes, IgG, IgA, IgM, CD4 +, CD4 + / CD8 + of the two groups were measured and statistically analyzed. Results There was no difference in age and APACHEⅡ between the two groups. There was no difference in lymphocyte count, IgG, IgA, IgM, CD4 +, CD4 + / CD8 + between the two groups before treatment, and lymphocytes (0.604 ± 0.123) IgG (11.71 ± 1.71), IgA (2.33 ± 0.18) and CD4 (36.11 ± 2.151), respectively, which were significantly higher than those in the control group (P <0.01). Conclusion Glutamine-enriched enteral nutrition can improve the immune function of sepsis patients and improve the prognosis of patients with sepsis.