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目的诱导抗双链ＤＮＡ抗体和其它抗核抗体生成的免疫原是什么？迄今不明。本研究试图阐明不同原因活化的淋巴细胞是诱导抗核抗体生成的免疫原。方法用丝裂原（ＣｏｎＡ／ＬＰＳ）或ＩＬ－２活化淋巴细胞及其染色质免疫同系ＢＡＬＢ／ｃ小鼠，用ＥＬＩＳＡ测定ＩｇＧ抗ｄｓＤＮＡ抗体，用免疫荧光法检测抗核抗体核型和免疫复合物沉积，用免疫印迹法测定抗Ｓｍ和抗ＲＮＰ等抗核抗体。结果上述原因活化的淋巴细胞及其活性染色质均能诱导抗双链ＤＮＡ抗体和其它抗核抗体生成，免疫小鼠的肾脏有显著的免疫复合物沉着。结论据本文结果推测活化淋巴细胞及其细胞核和染色质是诱发抗ｄｓＤＮＡ抗体和其它抗核抗体生成的免疫原。
What is the purpose of inducing immunogenicity of anti-dsDNA antibodies and other antinuclear antibodies? So far unknown. This study attempts to elucidate that activated lymphocytes of different origins are immunogens that induce the production of anti-nuclear antibodies. Methods BALB / c mice were immunized with ConA / LPS or IL-2-activated lymphocytes and their chromatin. The IgG anti-dsDNA antibody was detected by ELISA. The karyotype and immune complex of anti-nuclear antibody were detected by immunofluorescence The material was deposited and the anti-nuclear antibodies such as anti-Sm and anti-RNP were determined by immunoblotting. Results The above reasons activated lymphocytes and their active chromatin can induce anti-double-stranded DNA antibodies and other anti-nuclear antibody production, immunized mice kidney significant immune complex deposition. Conclusion According to the results of this paper, it is speculated that activated lymphocytes and their nucleus and chromatin are the antigens that induce the production of anti-dsDNA antibodies and other anti-nuclear antibodies.