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为探讨国产人静脉血丙种球蛋白（ＩＶＩＧ）对病毒性心肌炎的保护及治疗作用，取ＢＡＬＢ／ｃ小鼠随机分为ＩＶＩＧ保护组与治疗组。保护组接种柯萨奇Ｂ３病毒（ＣＶＢ３）后，立即使用剂量分别为２００ｍｇ·ｋｇ－１·ｄ－１、５００ｍｇ·ｋｇ－１·ｄ－１、１ｇ·ｋｇ－１·ｄ－１的ＩＶＩＧ７天。治疗组则将接种ＣＶＢ３后存活到１周的小鼠，使用上述三个剂量的ＩＶＩＧ治疗７天。１４天后处死动物。分别评价生存率、体重（ＢＷ）、心脏重量（ＨＷ）、心脏重／体重及心肌炎症的病理组织学改变。结果：保护组中５００ｍｇ及１ｇ组动物存活率１００％，未发生心肌炎症；２００ｍｇ组生存率为９５％，个别动物有轻微心肌炎症发生，与对照组比较差异显著（Ｐ＜０．０１）。治疗组心肌炎症均有减轻，发病症状减轻或消失，生存率提高，ＢＷ增加，ＨＷ及病灶面积较小，但２００ｍｇ组与对照组比较差异无显著性；５００ｍｇ及１ｇ组与对照组比较差异有显著性（Ｐ＜０．０５），但两者间差异无统计学意义。结论：国产人血冻干ＩＶＩＧ对ＣＶＢ３感染后的动物有保护及治疗作用
To investigate the protective and therapeutic effects of domestic intravenous gamma globulin (IVIG) on viral myocarditis, BALB / c mice were randomly divided into IVIG protection group and treatment group. Immediately after inoculation of Coxsackie B3 virus (CVB3) in the protection group, IVIG was administered at doses of 200 mg · kg-1 · d-1, 500 mg · kg-1 · d-1 and 1 g · kg-1 · d-1, respectively . In the treatment group, mice that survived one week after CVB3 inoculation were treated with the above three doses of IVIG for 7 days. Animals were sacrificed 14 days later. The histopathological changes of survival rate, body weight (BW), heart weight (HW), heart weight / body weight and myocardial inflammation were evaluated. Results: The survival rates of 500 mg and 1 g animals in the protection group were 100%, no myocardial inflammation occurred. The survival rate of the 200 mg group was 95%. Some animals had slight myocardial inflammation, which was significantly different from the control group (P <0.01). In the treatment group, the myocardial inflammation was alleviated, the symptom alleviated or disappeared, the survival rate increased, the BW increased, the HW and the lesion area were small, but there was no significant difference between the 200 mg group and the control group; the difference between the 500 mg and 1 g groups and the control group was (P <0.05), but there was no significant difference between them. Conclusion: Domestic human blood freeze-dried IVIG can protect and treat CVB3-infected animals