The Zhuxi tungsten deposit in Jiangxi Province, South China, contains a total W reserve of about 2.86 Mt at an average grade of 0.54 wt％ WO3, representing the largest W deposit in the world. Numerous studies on the metallogeny of the deposit have included its timing, the ore-controlling structures and sedimentary host rocks and their implications for mineral exploration. However, the deep nappe structural style of Taqian-Fuchun metallogenic belt that hosts the W deposit, and the spatial shape and scale of deeply concealed intrusions and their sedimentary host rocks are still poorly defined, which seriously restricts the discovery of new deposits at depth and in surrounding areas of the W deposit. Modern 3D geological modeling is an important tool for the exploration of concealed orebodies, especially in brownfield environments. There are obvious density contrast and weak magnetic contrast in the ore-controlling strata and granite at the periphery of the deposit, which lays a physical foundation for solving the 3D spatial problems of the ore-controlling geological body in the deep part of the study area through gravity and magnetic modeling. Gravity data (1:50000) and aeromagnetic data (1:50000) from the latest geophysical surveys of 2016-2018 have been used, firstly, to carry out a potential field separation to obtain residual anomalies for gravity and magnetic interactive inversion. Then, on the basis of the analysis of the relationship between physical properties and lithology, under the constraints of surface geology and borehole data, human-computer interactive gravity and magnetic inversion for 18 cross-sections were completed. Finally, the 3D geological model of the Zhuxi tungsten deposit and its periphery have been established through these 18 sections, and the spatial shape of the intrusions and strata with a depth of 5 km underground were obtained, initially realizing “transparency” for ore-controlling bodies. According the analysis of the geophysical, geochemical, and geological characteristics of the Zhuxi tungsten deposit, we discern three principles for prospecting and prediction in the research area, and propose five new exploration targets in its periphery.