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目的：探讨口服可乐定对小儿全麻安氟醚吸入浓度的影响。方法：随机将２０ 例５～１３ 岁 Ａ Ｓ Ａ Ⅰ级择期全麻手术患儿分为两组（每组 １０ 例）进行比较，可乐定组（Ⅰ组）于术前９０～１００ ｍ ｉｎ 口服可乐定 ５ μｇ·ｋｇ－ １，并于术前 ３０ ｍ ｉｎ 给予 Ａｔｒｏｐｉｎｅ ０．０１５ ｍ ｇ·ｋｇ－ １ 和 Ｌｕｍ ｉｎａｌ２ ｍ ｇ·ｋｇ－ １肌注；对照组（Ⅱ组）只给 Ａｔｒｏｐｉｎｅ 和 Ｌｕｍ ｉｎａｌ，不服用可乐定。两组患儿全麻插管后，将血流动力学稳定作为主要控制条件，记录三个时点的氨氟醚吸入浓度。结果：Ⅰ组患儿氨氟醚吸入浓度显著减小，较Ⅱ约下降 ３０％ （ Ｐ＜ ０．０１）。结论：小儿口服可乐定作为术前用药可以明显地降低术中氨氟醚吸入浓度。
Objective: To investigate the effect of oral clonidine on inhaled concentration of enflurane in children under general anesthesia. Methods: A total of 20 children aged 5 ~ 13 years old undergoing general anesthesia were enrolled and divided into two groups (10 in each group). The patients in group C were given 90 ~ 100 mins before operation Clonidine 5 μg · kg-1 and Atropine 0.015 m g · kg-1 and Luminar2 m g · kg-1 intramuscularly 30 min before the operation; control group (group Ⅱ) only Atropine and Lum inal, do not take clonidine. After general anesthesia intubation in both groups, the hemodynamic stability was taken as the main control condition, and the inhalation concentration of enrofluid was recorded at three time points. Results: The inhalation concentration of enflurane in group Ⅰ was significantly decreased, about 30% lower than that of Ⅱ (P <0.01). Conclusion: Pediatric oral clonidine as a preoperative medication can significantly reduce intraoperative enflurane inhalation concentration.