论文部分内容阅读
目的 :探讨热性惊厥患儿外周血T淋巴细胞免疫功能的变化。方法 :应用APAAP法检测 82例热性惊厥患儿、40例上呼吸道感染患儿及 40例正常小儿T淋巴细胞亚群、CD2 5抗原在自然状态和PHA激活后的活化状态的百分率。结果 :热性惊厥患儿外周血中 ,CD3、CD4 、CD4 /CD8比值 ,均显著低于两对照组 ;热性惊厥患儿在自然状态下的CD2 5抗原表达率明显低于两对照组 ,经PHA刺激后 ,CD2 5抗原表达在各组均显著增多 ,但热性惊厥组仍低于两对照组。结论 :热性惊厥患儿存在着细胞免疫损害 ,这可能是热性惊厥发生和复发的一个重要因素。预防热性惊厥复发 ,必须从提高细胞免疫功能着手。
Objective: To investigate the changes of T lymphocyte immune function in peripheral blood of children with febrile seizures. Methods: The APAAP method was used to detect the percentage of T lymphocyte subpopulation in 82 children with febrile seizures, 40 children with upper respiratory tract infection and 40 normal children. The percentage of activated state of CD2 5 in both natural and PHA-activated states was measured. Results: The ratio of CD3, CD4 and CD4 / CD8 in peripheral blood of children with febrile seizures were significantly lower than those of the two control groups. The expression rate of CD2 5 in children with febrile seizures was significantly lower than that of the two control groups, After PHA stimulation, CD2 5 antigen expression in each group were significantly increased, but the febrile seizure group is still lower than the two control groups. CONCLUSIONS: There is cellular immunity damage in children with febrile seizures, which may be an important factor in the occurrence and recurrence of febrile seizures. Prevent the recurrence of febrile seizures, we must start from improving cellular immune function.