论文部分内容阅读
目的:探讨中国湖南汉族人群内皮脂肪酶Gly26Ser基因多态性与动脉粥样硬化性脑梗死的相关性,及其对血脂、颈动脉粥样硬化形成的影响。方法:采用聚合酶链反应和限制性片段长度多态性方法对中国湖南汉族266例ACI患者和91例正常对照者EL-Gly26Ser基因多态性分析。结果:在中国湖南汉族人群中,EL-Gly26Ser基因存在GG和GA2种基因型;2种基因型和等位基因频率在脑梗死组和对照组之间比较差异无显著性(P>0.05)。结论:EL-Gly26Ser基因多态性可能不是湖南汉族人群脑梗死的遗传易感基因。
Objective: To investigate the correlation between the Gly26Ser polymorphism of endothelical lipase and the degree of atherothrombotic cerebral infarction in Chinese Han population of Hunan province and its effect on the formation of lipids and carotid artery atherosclerosis. Methods: Polymerase chain reaction and restriction fragment length polymorphism was used to analyze the polymorphism of EL-Gly26Ser gene in 266 Han Chinese ACI patients and 91 normal controls. Results: There were GG and GA genotypes in EL-Gly26Ser in Hunan Han Chinese population. The frequencies of two genotypes and alleles were not significantly different between cerebral infarction group and control group (P> 0.05). Conclusion: EL-Gly26Ser polymorphism may not be the genetic predisposition to cerebral infarction in Hunan Han population.