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我院从1988年9月至1991年6月有7例局部晚期复发性直肠癌接受腹主动脉大剂量灌注化疗加药物滤过治疗。所用的药物是丝裂霉素C(MMC,40～50mg)和5-氟尿嘧啶(5FU,2000mg)7例中,5例疼痛缓解,2例肿瘤缩小。4例治疗后6～12个月死亡(平均生存10.5月);3例治疗后0.5～20个月,仍存活。
In our hospital from September 1988 to June 1991, 7 patients with locally advanced recurrent rectal cancer received high-dose infusion chemotherapy of abdominal aorta plus drug filtration. The drugs used were mitomycin C (MMC, 40-50 mg) and 5-fluorouracil (5 FU, 2000 mg). Among the 7 cases, 5 eased pain and 2 tumors shrank. Four patients died 6 to 12 months after treatment (average survival 10.5 months); 3 patients survived 0.5 to 20 months after treatment.