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目的:探讨脑梗死患者颈动脉粥样硬化的危险因素。方法:选取148例脑梗死患者作为实验组和同期住院的80例非脑梗死疾病患者为对照组,检测并比较各组年龄、吸烟、血压、饮酒、糖尿病、血脂、同型半胱氨酸和磷脂酶A2等指标,然后进行卡方检验、相关性和Logistic回归分析。结果:实验组颈动脉粥样硬化检出率为82.43%,对照组为12.5%,其差异具有统计学意义(P<0.05)。高龄、吸烟、高血压、高血脂、高同型半胱氨酸血症、高磷脂酶A2(LP-PLA2)血症是经动脉粥样硬化的危险因素,且血浆同型半胱氨酸水平、LP-PLA2水平、血压与颈动脉斑块稳定性有关(P<0.05)。结论:颈动脉粥样硬化是脑梗死的病理基础,与高龄、吸烟、高血压、高血脂、高同型半胱氨酸血症、高磷脂酶A2(LP-PLA2)血症有关,对高同型半胱氨酸血症、LP-PLA2和高血压患者要关注其斑块的稳定性。
Objective: To explore the risk factors of carotid atherosclerosis in patients with cerebral infarction. Methods: A total of 148 patients with cerebral infarction were selected as experimental group and 80 non-cerebral infarction patients hospitalized in the same period as control group. The age, smoking, blood pressure, alcohol consumption, diabetes mellitus, serum lipids, homocysteine and phospholipid Enzyme A2 and other indicators, and then chi-square test, correlation and Logistic regression analysis. Results: The detection rate of carotid atherosclerosis was 82.43% in the experimental group and 12.5% in the control group, the difference was statistically significant (P <0.05). Elderly, smoking, hypertension, hyperlipidemia, hyperhomocysteinemia, hyperphospholipase A2 (LP-PLA2) hyperlipidemia are risk factors of atherosclerosis, and plasma homocysteine level, LP -PLA2 levels, blood pressure and carotid plaque stability (P <0.05). Conclusion: Carotid atherosclerosis is the pathological basis of cerebral infarction, which is associated with aging, smoking, hypertension, hyperlipidemia, hyperhomocysteinemia and hyperphospholipase A2 (LP-PLA2) Cysteinemia, LP-PLA2 and hypertensive patients should pay attention to the stability of its plaque.