论文部分内容阅读
胰腺炎相关蛋白( PAP)是一种公认的新型抗炎症因子,与胰腺炎的发生、发展密切相关,在患有心肌梗死、心力衰竭等心血管疾病时,胰腺炎相关蛋白表达水平也会明显上调;可作为心力衰竭辅助诊断、程度分级、治疗效果评估及预后判定的新型生物学标志物。 PAP不仅对心肌梗死后心肌修复具有重要作用,而且在早期识别药物性心脏毒性反应中也有重要价值。许多研究对其在心血管疾病中的抗炎症反应、抗细胞凋亡等相关作用机制进行了研究,并取得了一些新进展。“,”Pancreatitis-associated protein ( PAP) is a novel cytokine with well-established anti-inflam-matory effects,which is closely related to the development of pancreatitis,and is significantly upregulated in the cases of myocardial infarction, heart failure and other cardiovascular diseases.It can be used as a new biomarker in the diagnosis, grading, treatment and prognosis assessment of heart failure.It plays an impor-tant role not only in myocardial healing after myocardial infarction ,but also in the early identification of drug-induced cardiac toxicity.Many studies have been done on its mechanisms such as anti-inflammatory reaction and resistance to apoptosis in cardiovascular diseases, and some new progress has been made.