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家犬1次口服吡喹酮缓释片(SRPT)200mg/kg,体内药代动力学特性可用一室开放模型描述,与平行对照的吡喹酮普通片(PZQT)相比,Cmax下降,Tmax推迟,有效血药浓度时间延长,而生物利用度没有显著改变。按20mg/kg×2,1d内服用,血药浓度长时间维持在有效浓度以上,第27h血药浓度为2μg/ml,无明显峰谷现象。以1d内服用30mg/kg×2剂量治疗人工感染的家犬日本血吸虫病,减虫率为93.61％,与平行对照的PZQT相比,疗效无显著差异(p>0.05)。
The oral administration of praziquantel sustained-release tablets (SRPT) 200 mg / kg was given once daily to the domestic dogs. The in vivo pharmacokinetic properties of the dogs can be described by a one-compartment open model. Cmax decreased and Tmax decreased compared with PZQT Postponed, prolonged effective plasma concentration, and bioavailability did not change significantly. By 20mg / kg × 2,1d taken within a long time to maintain the plasma concentration of effective concentration for more than 27h blood concentration of 2μg / ml, no significant peak valley phenomenon. The treatment of artificially infected domestic schistosomiasis japonicum with 30 mg / kg × 2 dose within 1 day was 93.61%, which showed no significant difference (P> 0.05) compared with that of the parallel control PZQT.