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目的探讨颅脑外伤术后颅内感染的相关因素。方法选取郑州大学第一附属医院颅脑外伤术后颅内感染者34例设为观察组,同期术后未出现颅内感染者42例设为对照组,对单因素及多因素非条件Logistic回归分析进行比较。结果单因素分析表明年龄、开放性伤口、术前GCS评分、脑室外引流、手术时间、手术次数、术后切口脑脊液漏等因素均为颅内感染的相关危险因素(P<0.05)。多因素非条件Logistic回归分析表明,术后切口脑脊液漏、脑室外引流及手术时间是颅内感染的独立高危险因素(P<0.05)。结论术后切口脑脊液漏、脑室外引流及手术时间是颅内感染的独立高危险因素,应针对高危因素患者及时采取预防性处理措施,降低术后颅内感染的发生率。
Objective To explore the related factors of intracranial infection after craniocerebral trauma. Methods 34 cases of intracranial infection after craniocerebral trauma in the First Affiliated Hospital of Zhengzhou University were selected as the observation group and 42 cases without intracranial infection in the same period as the control group.The univariate and multivariate non-conditional logistic regression Analysis for comparison. Results Univariate analysis showed that age, open wound, preoperative GCS score, extrahepatic ventricular drainage, operation time, number of operations and postoperative cerebrospinal fluid leakage were all risk factors of intracranial infection (P <0.05). Multivariate non-conditional Logistic regression analysis showed that postoperative cerebrospinal fluid leakage, ventricular extravasation and operation time were independent high risk factors for intracranial infection (P <0.05). Conclusions Postoperative cerebrospinal fluid leakage, extracerebral ventricular drainage and operative time are independent high risk factors for intracranial infection. Preventive measures should be taken in patients with risk factors to reduce the incidence of postoperative intracranial infection.