醋炔诺酮肟是一种极有希望的新避孕药,但其长期使用时的安全性如何,尚待作出评价。本文采用微核试验测定了醋炔诺酮肟对小鼠骨髓细胞微核率的影响,其目的是了解醋炔诺酮肟对生物细胞的遗传物质是否具有致突变作用,进而有助于对长期使用醋炔诺酮肟的安全、毒性问题作出评定。突变是生物细胞的遗传物质出现了可被觉察的变化。从毒理学的角度,突变是某些 Norethindrone acetate is a promising new pill, but its safety during long-term use remains to be evaluated. In this paper, micronucleus test was used to determine the effect of norgestimate oxime on the micronuclei of mouse bone marrow cells. The purpose of this study is to understand whether norethisterone oxime has a mutagenic effect on the genetic material of biological cells, Use of norethisterone oxime safety, toxicity issues to be assessed. Mutations are the observable changes in the genetic material of a living cell. From a toxicological point of view, mutations are some