论文部分内容阅读
作者复习了有关长期用抗癫药物引起周围神经病的文献,一般均归之于苯妥因钠(DPH)所引起,但作者认为这些报告的结论忽视了其他抗癫癎药物的同时使用,因为这些文献的494例中单独用DPH者仅14例.为此作者在186例癫癎病人中研究了长期用抗癫癎药物(DPH、鲁米那、扑癎酮、酰胺味嗪等)对周围神经的作用,周围神经病的发病率为16.7%,其表现为周围型感觉导常及踝反射消失,电生理测定提示腓神经及腓肠神经的神经传导速度(NCV)变慢,以及H发射与F反应延迟或消失.通过临床及电生理观察,并对照40例正常人的结果,发现用抗癫癎药物者其电生理指标的异常均较正常对照组明显(P<0.05以下),各种抗癫癎药长期应用均能引起
The authors reviewed the literature on the long-term use of antiepileptic drugs to cause peripheral neuropathy, usually due to phenytoin sodium (DPH), but the authors concluded that the conclusions of these reports ignore the simultaneous use of other antiepileptic drugs because these In the literature, only 49 of the 494 patients were treated with DPH alone, only 14 of 186 patients with epilepsy were investigated for long-term use of anti-epileptic drugs (DPH, luminal, puerarin, amide, etc.) The incidence of peripheral neuropathy was 16.7%, which showed peripheral sensory anomaly and ankle reflex disappearance. Electrophysiological measurements suggested slowing of nerve conduction velocity (NCV) of the peroneal nerve and sural nerve, Reaction delay or disappear.Through clinical and electrophysiological observation, and the control of 40 cases of normal people’s results and found that the use of anti-epileptic drugs, electrophysiological abnormalities were significantly more than the normal control group (P <0.05), a variety of anti- Long-term use of epileptic drugs can cause