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目的:研究大鼠α1肾上腺素能受体在胃粘膜和粘膜下层的分布和梗阻性黄疸时密度的变化。方法:16只Wistar大鼠分成正常组与黄阻性黄疸组,每组8只。并采用光学显微镜放射自显影术。结果:大鼠胃粘膜无α1肾上腺素能受体。α1肾上腺素能受体分布在胃粘膜下层动脉平滑肌细胞表面。正常大鼠α1肾上腺素能受体密度在胃体大干胃窦,梗阻性黄疸时α1肾上腺素能受体密度明显减少。结论:由于α1肾上腺素能受体密度在胃体大于胃窦,所以交感-肾上腺素系统对胃体血流的影响大于胃窦。梗阻性黄疸α1肾上腺素能受体明显减少,可能是胃粘膜下血管对去甲肾上腺素敏感性降低的原因之
OBJECTIVE: To study the distribution of rat α1 adrenergic receptor in gastric mucosa and submucosa and the density change of obstructive jaundice. Methods: Sixteen Wistar rats were divided into normal group and yellow resistance jaundice group, with 8 in each group. And using optical microscope autoradiography. Results: There was no α1 adrenergic receptor in rat gastric mucosa. α1 adrenergic receptor distribution in the gastric submucous artery smooth muscle cell surface. The normal rat α1 adrenergic receptor density in the gastric body large dry antrum, obstructive jaundice α1 adrenergic receptor density was significantly reduced. CONCLUSION: The sympathetic-adrenergic system has a greater effect on gastric blood flow than the gastric antrum due to the greater α1 adrenergic receptor density in the gastric body than the antrum. Obstructive jaundice α1 adrenergic receptor decreased significantly, may be the reason of gastric mucosal vascular sensitivity to norepinephrine