【摘 要】
：
Dear Editor,rnAn increasing number of single-cell RNA-seq(scRNA-seq)studies gained deep insights into the gene expression het-erogeneity among individual cells
【机 构】
：
Center for Bioinformatics and Computational Biology,and Shanghai Key Laboratory of Regulatory Biolog
论文部分内容阅读
Dear Editor,rnAn increasing number of single-cell RNA-seq(scRNA-seq)studies gained deep insights into the gene expression het-erogeneity among individual cells by cell type/state identi-fication(Chen et al.,2019).Alternative splicing(AS)enables genes to generate multiple isoforms through the combination of disparate exons to increase the diversity of transcriptome(Lee and Rio,2015).Additionally,gene reg-ulatory network(GRN)is crucial for understanding the mechanism of gene expression regulation(Aibar et al.,2017).Human pancreas is essential for maintaining meta-bolic homeostasis;however,the AS changes and GRN dif-ferences across different pancreatic islet types are still largely unknown.
其他文献
It is recognized that HIV-1 capsid cores are disassembled in the cytoplasm,releasing their genomes into the nucleus through nuclear pores,but there is also evid
录井系统作为一套在钻井井场中工作的电气系统,需要多种防护技术,尤其是防爆技术,其在录井设备上应用多年.但是,随着防爆技术的应用,其在录井系统中出现了一些问题.本文根据
为满足吐哈油田数字化建设的需求,吐哈录井工程公司自2005年开始以井场信息远程传输系统为基础逐步拓展完善功能应用,至2009年基本完成了涵盖录井作业整个过程的录井信息平台
随着数据通信及互联网技术的发展,网络RTK技术应运而生,其应用在CORS系统中彻底改变了常规RTK测量作业方式.本文介绍了胜利油区单基站CORS系统的构建情况及其关键技术,对该系
As a conserved transcription factor,FoxO plays a crucial role in multiple physiological processes in vivo,including stress resistance,longevity,growth and repro
长岭断陷菅城组火山岩发育,近年来将其作为重点勘探对象,完成了20多口井钻探,取得了大量的岩心、岩屑、钻时、气测参数等录井资料.通过岩性剖面分析、岩心观察测量,对火山岩
为了满足水平井钻井过程中对目标体的快速综合分析和现场地质导向,开发了集地质、录井、钻井工程、随钻测量于一体的水平井随钻监控与分析技术平台,该平台首次实现几何导向与
潜山油藏一般属于裂缝型块状油藏,其优势储层划分实质上是对于潜山裂缝发育程度的界定及其所合流体的性质识别.本文通过对潜山裂缝的研究,认为使用优选的录井参数,利用数学模
In this article,we investigate the orbit configuration spaces of some equivariant closed manifolds over simple convex polytopes in toric topology,such as small
本文就新型岩化技术的勘探需求和技术现状、方法原理和技术优势、现场应用和效果分析等进行了介绍,评价了该技术的应用前景,为下一步在碳酸盐岩探区的推广应用提供了指导.一