【摘 要】
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Dear Editor,rnAn increasing number of single-cell RNA-seq(scRNA-seq)studies gained deep insights into the gene expression het-erogeneity among individual cells
【机 构】
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Center for Bioinformatics and Computational Biology,and Shanghai Key Laboratory of Regulatory Biolog
论文部分内容阅读
Dear Editor,rnAn increasing number of single-cell RNA-seq(scRNA-seq)studies gained deep insights into the gene expression het-erogeneity among individual cells by cell type/state identi-fication(Chen et al.,2019).Alternative splicing(AS)enables genes to generate multiple isoforms through the combination of disparate exons to increase the diversity of transcriptome(Lee and Rio,2015).Additionally,gene reg-ulatory network(GRN)is crucial for understanding the mechanism of gene expression regulation(Aibar et al.,2017).Human pancreas is essential for maintaining meta-bolic homeostasis;however,the AS changes and GRN dif-ferences across different pancreatic islet types are still largely unknown.
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