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静注丙种球蛋白(IVIG)是人源血提取制品,包含结构和功能完整的免疫球蛋白。鉴于其具有抗炎和免疫调理作用和可能的某些抗病毒特异性,IVIG在诸如新生儿溶血性黄疸、免疫缺陷病、川崎病、儿童特发性血小板减少性紫癜、格林巴利综合征、原发、继发或获得性免疫缺陷中反复发生的感染等儿科疾病的治疗中有过尝试应用,并在部分上述病症中收到一定的疗效。同时随着时间推移,IVIG使用中的副作用也越来越多地被认识和重视。本文对IVIG在儿科疾病中的应用作一综述。
Intravenous gammaglobulin (IVIG) is a human blood extract that contains structurally and functionally intact immunoglobulins. In view of their anti-inflammatory and immunomodulatory effects and possibly some antiviral specificity, IVIG is widely used in the treatment of diseases such as neonatal hemolytic jaundice, immunodeficiency disease, Kawasaki disease, idiopathic thrombocytopenic purpura, Guillain-Barre syndrome, Attempts have been made to treat pediatric diseases such as recurrent infections in primary, secondary or acquired immunodeficiency and to some extent in some of these conditions. As time goes on, side effects in the use of IVIG are also increasingly recognized and valued. This article reviews the use of IVIG in pediatric diseases.