细小病毒科是由微小的、无包膜核复制病毒构成,其含有一个基本单链的线性DNA基因组。某些细小病毒具有亲瘤性和对肿瘤细胞作用的专一性,能阻止肿瘤形成,并对已形成的肿瘤具有抑制生长的作用。对某些特殊的致癌基因,细小病毒具有使细胞静止的作用,并将转化过程逆转。这些性质表明,可以利用细小病毒作为探针,研究肿瘤恶变转化的过程,乃至有可能以细小病毒来防治人类癌症。 The Parvoviridae are composed of tiny, non-enveloped nuclear replication viruses that contain a single, single-stranded linear DNA genome. Certain parvoviruses have a neoplastic nature and specificity for the action of tumor cells, can prevent tumor formation, and have a growth-inhibitory effect on already formed tumors. For certain special oncogenes, the parvovirus has the effect of quiescent cells and reverses the transformation process. These properties indicate that the parvoviruses can be used as probes to study the malignant transformation of tumors, or even to use parvovirus to control human cancers.