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目的:探讨吸烟对无其他心血管危险因素的年轻勃起功能障碍(ED)患者内皮功能的影响。方法:我院泌尿外科门诊和住院ED患者,其中吸烟组21例,非吸烟组48例,健康对照组16例,所有受试者均进行肱动脉血流介导的内径扩张功能(FMD)的测定,同时检测其血压、血糖、血脂等指标。结果:与健康对照组相比,ED组患者FMD明显降低,而ED组中吸烟组FMD又明显低于非吸烟组[吸烟组(6.0±0.8)%,非吸烟组(9.7±2.5)%,对照组(14.0±2.5)%],组间差异均有统计学意义(P<0.05)。结论:ED患者存在内皮功能障碍,吸烟进一步加重ED患者内皮功能的损害。
Objective: To investigate the effect of smoking on endothelial function in patients with young erectile dysfunction (ED) without other cardiovascular risk factors. Methods: Urology clinic and hospitalized ED patients were recruited in this study. Among them, 21 were smoker group, 48 were non-smoker group and 16 were healthy control group. All subjects underwent brachial artery blood flow-mediated dilatation (FMD) Determination, while testing its blood pressure, blood glucose, blood lipids and other indicators. Results: The FMD in ED group was significantly lower than that in healthy control group, while the FMD in ED group was significantly lower than that in non-smoking group [6.0 ± 0.8% vs 9.7 ± 2.5% Control group (14.0 ± 2.5)%], the differences between the groups were statistically significant (P <0.05). Conclusion: There is endothelial dysfunction in ED patients. Smoking further aggravates endothelial dysfunction in ED patients.