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早在15年前,国外就开始对阿司匹林在心血管疾病中的有益作用进行了大规模的调查研究。随着对血小板在血栓形成发展过程中的作用的认识不断深入,人们更加重视阿司匹林的抗血栓作用在临床的应用,并在以阿司匹林作为心血管血栓的辅助治疗中取得了显著的效果。1 作用机制阿司匹林抗血小板作用的主要机制是将血小板环氧酶乙酰化,作用的部位是环氧酶活性部位的丝氨酸
As early as 15 years ago, foreign countries began to conduct a large-scale investigation of the beneficial effects of aspirin in cardiovascular diseases. With the deepening understanding of the role of platelets in the development of thrombosis, people pay more attention to the clinical application of aspirin’s antithrombotic effect and have achieved remarkable results in the adjuvant therapy with aspirin as a cardiovascular thrombus. 1 Mechanism of action Aspirin anti-platelet effect is the main mechanism of acetylation of platelet cyclooxygenase, the role of site is the active site of cyclooxygenase serine