斯伐他丁(simvastatin,SIM)是一种新型的羟基-β-甲基-戊二酸单酰辅酶 A 还原酶抑制剂,具有显著的降低血中胆固醇和甘油三酯的作用,但目前该药对甘油三酯的作用机理尚不清楚。选择患有高胆固醇血症及非胰岛素依赖性糖尿病的老年受试者12名,实验前3周内受试者不得服用降血糖药或其它药物,每日饮食含5.2mmol 胆固醇及至少250g 碳水化合物。采用随机、双盲交叉实验。两组分别给SIM 30mg/d 及安慰剂,持续3周,停药3周后,互换药物。每次给药3周后禁食过夜(至少12h),再随机进行:(1)口服75g 葡萄糖耐量试验(OGTT);(2)血糖正常的高胰岛素血症的葡萄糖维持实验(进行120 min)。实验表明,较之安慰剂,SIM 能显著降低血浆总胆固醇(7.9对5.3 mmol·L~(-1),p<0.001)、LDL 胆固醇(7.2对4.3mmol·L~(1-),p<0.001)、甘油三酯(2.9对2.1 Simvastatin (SIM), a novel hydroxy-β-methyl-glutaryl coenzyme A reductase inhibitor, has significant effects of lowering blood cholesterol and triglycerides, but at present, The mechanism of action of the drug on triglycerides is not clear. Twelve elderly subjects with hypercholesterolemia and non-insulin-dependent diabetes were selected. Subjects should not take hypoglycemic agents or other medications within 3 weeks prior to the experiment. The daily diet consisted of 5.2 mmol of cholesterol and at least 250 g of carbohydrates . Randomized, double-blind crossover experiment. The two groups were given SIM 30mg / d and placebo for 3 weeks, 3 weeks after drug withdrawal, the exchange of drugs. Fasting (at least 12 h) was performed overnight after 3 weeks of each dose and then randomized: (1) oral glucose tolerance test (OGTT) of 75 g; (2) glucose maintenance test of hyperglycemia with normal blood glucose (for 120 min) . Experiments showed that SIM significantly reduced plasma total cholesterol (7.9 vs. 5.3 mmol·L -1, p <0.001), LDL cholesterol (7.2 vs. 4.3 mmol·L -1, p < 0.001), triglycerides (2.9 vs. 2.1