This article describes the clinical char-acteristics of a case of cerebral infarction complicated with pulmonary embolism (PE), and elaborates the ther-apeutic strategies of intravenous thrombolysis and anti-coagulation. Treatment remedies: the medical history and examination data of a patient with aphasia and right hemiplegia were collected. After intravenous thrombol-ysis and pulmonary artery CTA (computed tomographic angiography), the patient was found to have low blood oxygen saturation and PE. And the patient was treated with anticoagulant therapy. Post treatment evaluating: cerebral hemorrhage was excluded by craniocerebral CT (computed tomographic), and left basal ganglia infarc-tion was diagnosed. After thrombolysis, the symptoms of aphasia and hemiplegia were significantly improved. For PE, after anticoagulant therapy, the patient's breathing was stable and blood oxygen saturation was normal. For deep venous thrombosis of both lower extremities, anti-coagulant therapy was continued. Conclusion: patients with thrombophilia are prone to cerebral embolism, PE and deep venous thrombosis of lower limbs. Intravenous thrombolytic therapy in acute phase and heparin antico-agulant therapy in recovery period can effectively control the disease.