甲胎蛋白是一种a_1球蛋白,在正常胎儿血清中有高浓度存在,生后则仅有极少量。虽然甲眙蛋白的许多理化性质已经了解,但它的本体发生至今未明。1963年A belev等发现在实验性化学物诱发肝癌的成年大白鼠血清中有一具有眙儿特性的a球蛋白。随即Tatarinov发现在原发性肝癌的病人血清中有甲胎蛋白存在,提示有可能用一种免疫化学的际记物作为旰癌的诊断。其价值已为世界上许多地区广泛的研究证实和肯定。然而有关这种蛋白质在疾病过程中的动力学了解很少,而其被肿瘤再合成的原因则知之更少。 Alpha-fetoprotein is a alpha globulin, which is present in high concentrations in normal fetal serum and is only minimal after birth. Although many physicochemical properties of formazan protein have been known, its ontogenesis has not been known so far. In 1963, A belev et al. found that there was a globulin protein in the adult rat serum induced by experimental chemical liver cancer. Tatarinov then discovered that alpha-fetoprotein was present in the serum of patients with primary liver cancer, suggesting that it may be possible to use an immunochemical interrogator as a diagnosis of carcinoid cancer. Its value has been confirmed and confirmed by extensive research in many parts of the world. However, little is known about the dynamics of this protein in the disease process, and less is known about the causes of its resynthesis.