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目的研究体检人群血糖(GLU)与血浆致动脉硬化指数(AIP)、超敏C反应蛋白(HCRP)、血脂系列等指标的相关性,为临床评估高血糖及并发心脑血管疾病风险提供实验检测依据。方法使用奥林巴斯AU5400全自动生化分析仪测定9 057名体检人员GLU、HCRP及血脂系列等指标,计算AIP值,用t检验或方差分析不同性别、年龄、血糖组间这些测定指标的差异;采用Pearson相关分析各指标之间的相关性,再用多因素Logistic回归分析高血糖的相关危险因素。结果男女高血糖组AIP、HCRP水平均高于非高血糖组人群(P<0.01)。GLU与AIP、载脂蛋白B(apoB)、HCRP、低密度脂蛋白-胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、尿酸(URIC)、apoB/apoA1呈较低程度的正相关,其中与AIP相关性最高(r=0.163,P<0.01);GLU与载脂蛋白A1(apoA1)、高密度脂蛋白胆固醇(HDL-C)呈负相关。多因素Logistic回归分析显示:男性、年龄、HCRP、AIP和高血糖存在关联。结论高血糖人群的AIP、HCRP平均水平高于非高血糖人群。建议2型糖尿病患者应重视血糖、AIP和HCRP等指标的监控,以为防止并发心脑血管疾病。
Objective To study the correlation between GLU and AIP, HCRP, blood lipid series and other indicators in medical examination population to provide experimental evidence for the clinical assessment of the risk of hyperglycemia and cardiovascular and cerebrovascular diseases in accordance with. Methods Using Olympus AU5400 automatic biochemical analyzer to measure the GLU, HCRP, blood lipid and other indicators of 9 057 medical staff, calculate the AIP value, using t test or variance analysis of different gender, age, blood glucose among these indicators Pearson correlation analysis was used to analyze the correlation between each index, and multivariate Logistic regression was used to analyze the related risk factors of hyperglycemia. Results The levels of AIP and HCRP in male and female hyperglycemia groups were higher than those in non-hyperglycemia groups (P <0.01). GLU was lower with AIP, apoB, HCRP, LDL-C, TC, triglyceride, uric acid and apoB / apoA1 (R = 0.163, P <0.01). There was a negative correlation between GLU and apolipoprotein A1 (apoA1) and high density lipoprotein cholesterol (HDL-C). Multivariate logistic regression analysis showed that men, age, HCRP, AIP and hyperglycemia were related. Conclusion The average level of AIP and HCRP in hyperglycemic subjects is higher than in non-hyperglycemic subjects. It is suggested that patients with type 2 diabetes should pay attention to the monitoring of indicators such as blood glucose, AIP and HCRP in order to prevent the concurrent cardiovascular and cerebrovascular diseases.