地高辛过大剂量难以治疗,死亡率为10～20％。阿托品对轻度过量有效,但对严重中毒患者无多大价值。苯妥英钠对中度中毒患者有效,但对严重病例,常规抗心律失常药物如利多卡因、苯妥英钠、心得安、普鲁卡因酰胺和异搏停似乎无效。特异性地高辛抗体虽然有效,但尚未广为采用。甚至心脏起搏对严重中毒患者也无效。作者报道1例地高辛过大剂量出现难治性室颤,静注乙胺碘呋酮后救治成功。患者26岁,男性。服地高辛0.25mg100片,在18小时后入院。入院检查发现窦性心动过缓,心率50 Digoxin overdose large dose difficult to treat, the mortality rate of 10 to 20%. Atropine on mild over-effective, but not much value to patients with severe poisoning. Phenytoin sodium is effective in moderately toxic patients, but in severe cases, conventional antiarrhythmic drugs such as lidocaine, phenytoin sodium, propranolol, procainamide and verapamil appear to be ineffective. Specific anti-digoxin antibodies are effective but have not been widely adopted. Even cardiac pacing is also ineffective in patients with severe poisoning. The authors reported a case of intractable ventricular fibrillation overdose of digoxin, intravenous amiodarone treatment after the success. Patient 26 years old, male. Take digoxin 0.25mg100 tablets, admitted after 18 hours. Sinus examination found sinus bradycardia, heart rate 50