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目的评价第6秒用力呼气容积(FEV6)和第1秒用力呼气容积(FEV1)/FEV6在煤矿工人肺功能评价中的应用价值。方法对420例男性煤矿工人进行时间肺活量测定,分析FEV6与用力肺活量(FVC)、FEV1/FEV6与FEV1/FVC的相关性;以FEV1/FVC<70%和FVC<80%为金标准,绘制受试者工作特征(ROC)曲线,确定诊断界值。结果 FEV6与FVC相关系数为0.997 0(P<0.000 1),FEV1/FEV6和FEV1/FVC Spearman相关系数为0.999 8(P<0.000 1)。FEV1/FEV6和FEV6的ROC曲线下面积分别为1.000和0.967,95%可信区间分别为(0.991,1.000)和(0.946,0.982),确定FEV1/FEV6和FEV6最佳分界点为69.92%和83.52%。结论 FEV6和FEV1/FEV6可替代FVC和FEV1/FVC用于煤工尘肺肺功能评价。
Objective To evaluate the value of 6th second forced expiratory volume (FEV6) and 1 second forced expiratory volume (FEV1) / FEV6 in lung function assessment of coal miners. Methods The time spirometry was performed on 420 male coal miners. The correlation between FEV6 and forced vital capacity (FVC), FEV1 / FEV6 and FEV1 / FVC was analyzed. The FEV1 / FVC <70% and FVC <80% The characteristics of the trial (ROC) curve, to determine the diagnostic boundary value. Results The correlation coefficient between FEV6 and FVC was 0.997 0 (P <0.000 1), and the Spearman correlation coefficient between FEV1 / FEV6 and FEV1 / FVC was 0.999 8 (P <0.000 1). The areas under the ROC curve for FEV1 / FEV6 and FEV6 were 1.000 and 0.967, respectively. The 95% confidence intervals were (0.991, 1.000) and (0.946, 0.982), respectively. The best cutoff points for FEV1 / FEV6 and FEV6 were 69.92% and 83.52 %. Conclusion FEV6 and FEV1 / FEV6 can replace FVC and FEV1 / FVC for lung function evaluation of coal workers’ pneumoconiosis.