【摘 要】
:
HIV整合酶是病毒DNA复制所必需的3个基本酶之一,是新批准上市的抗艾滋病药物Raltegravir(MK-0518,Isentress)的分子靶标.HIV整合酶抑制剂已经成为新一类治疗获得性免疫缺陷综
【机 构】
:
中国科学院上海药物研究所新药研究国家重点实验室药物设计和发现中心,中国药科大学药学院,
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HIV整合酶是病毒DNA复制所必需的3个基本酶之一,是新批准上市的抗艾滋病药物Raltegravir(MK-0518,Isentress)的分子靶标.HIV整合酶抑制剂已经成为新一类治疗获得性免疫缺陷综合症的药物.对HIV整合酶抑制剂的研究进展进行了综述,为研究新型人类免疫缺陷病毒整合酶抑制剂提供参考.
HIV integrase, one of the three essential enzymes necessary for viral DNA replication, is the molecular target of the newly approved anti-AIDS drug Raltegravir (MK-0518, Isentress), and HIV integrase inhibitors have become a new class of therapeutically available Immunodeficiency syndrome drugs.Investigation on the progress of HIV integrase inhibitors are reviewed and provide a reference for the study of novel human immunodeficiency virus integrase inhibitors.
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