Aurora激酶家族是一组近年来发现的调节中心体和微管功能的丝氨酸/苏氨酸蛋白激酶,在细胞有丝分裂的正常进程中起着非常重要的作用。相关研究表明在一些实体肿瘤如乳腺癌、卵巢癌、食管癌、结肠癌、肺癌及膀胱癌等肿瘤中均出现Aurora-A基因的高表达。目前,Aurora-A激酶作为肿瘤治疗的一个新的靶点,已经逐渐引起人们重视,其小分子抑制剂的研究和使用,尤其是与化疗药物的联合应用,将成为今后恶性肿瘤治疗的新方向。本文对近几年国内外在Aurora-A激酶的研究,对其生物学功能、与肿瘤的关系及其抑制剂的研究进展进行综述。 The Aurora kinase family is a group of serine / threonine protein kinases that have been found in recent years to regulate centrosomes and microtubule functions and play an important role in the normal process of cell mitosis. Related studies have shown that in some solid tumors such as breast cancer, ovarian cancer, esophageal cancer, colon cancer, lung cancer and bladder cancer tumors Aurora-A gene are highly expressed. Currently, Aurora-A kinase as a new target of tumor therapy has gradually attracted people's attention. The research and application of its small molecule inhibitors, especially with chemotherapy drugs, will become the new direction of the future treatment of malignant tumors . In this paper, the recent years at home and abroad Aurora-A kinase research, its biological function, the relationship with the tumor and the progress of its inhibitors are reviewed.