门脉高压的药物治疗旨在减少门静脉的血流量和降低肝内血管阻力,因而临床上主要选用血管收缩剂和血管扩张剂。1.血管收缩剂:加压素对脾动脉和肠系膜动脉具有明显的收缩作用,可减少进入门脉系统的血流量,致使门脉压力下降。另外,该药还可减少静脉血流,有助于治疗食管静脉曲张出血。由于加压素对内脏血管床的作用远比其他部位强,故有人提出经动脉滴注加压素可以增加局部效应,减少对全身 Portal hypertension drug treatment aims to reduce the portal vein blood flow and reduce intrahepatic vascular resistance, and thus clinically the main selection of vasoconstrictors and vasodilators. Vasoconstrictor: vasopressin on the splenic artery and mesenteric artery has a significant contraction, can reduce the blood flow into the portal system, resulting in decreased portal pressure. In addition, the drug can reduce venous flow, help treat esophageal variceal bleeding. Because of the role of vasopressin on the visceral vascular bed is much stronger than other parts, it was suggested that the arterial infusion of vasopressin can increase the local effect, reduce the body