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目的 观察Ｉｒｂｅｓａｒｔａｎ对血管损伤后内膜增殖的作用。方法２４只髂总动脉球囊内膜剥脱的Ｗｉｓｔａｒ大鼠随机等分为三组，分别于本前１天至术后１４天食管内喂饲Ｉｒｂｅｓａｒｔａｎ ３０ｍｇ／ｋｇ·ｄ或蒸馏水。术后１４天对损伤血管进行形态学检查。结果 Ｉｒｂｅｓａｒｔａｎ显著抑制损伤血管壁中细胞计数增加和内膜增厚以及血管平滑肌细胞增殖，并且有量效关系。对新生内膜中细胞密度影响不大。结论 Ｉｒｂｅｓａｒｔａｎ能够抑制大鼠髂总动脉球囊损伤后内膜增殖，Ｉｒｂｅｓａｒｔａｎ可能是防治血管成形术后再狭窄的有效药物。
Objective To observe the effect of Irbesartan on intimal hyperplasia after vascular injury. Methods Twenty-four Wistar rats were randomly divided into three groups: Irbesartan 30 mg / kg · d or distilled water in the former one day and 14 days after the operation. Morphological examination of injured vessels was performed 14 days after operation. Results Irbesartan markedly inhibited the increase of cell count and intimal thickening and the proliferation of vascular smooth muscle cells in injured vessel wall, and showed a dose-response relationship. Neointima cell density little effect. Conclusion Irbesartan can inhibit intima proliferation after balloon injury of common iliac artery in rats. Irbesartan may be an effective anti-stenosis after angioplasty.