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由于Tolypocladium inflatum可产生由11个氨基酸组成的环状肽类——环孢菌素,故在生物技术上甚为重要。环孢菌素A(cyclosporin或ciclosporin)作为移植外科上的关键性药物,对于所移植的同种器官的排异反应显示了很强的选择性免疫抑制活性,它对自体免疫病和寄生物病也是一种很有希望的药物。最近Weiser等的研究证明了环孢菌素A的昆虫致病活性。除了T.inflatum外,据报道,其它Tolypocladium属菌种和栖息于土壤的真菌如:腐皮镰孢霉(Fusarium solani)和Neocosmospora vasinfecta亦产生少量环孢菌素。通常,由真菌产生的杀昆虫化合物对虫类都是致命的。真菌系透过角度层使寄生昆
Because Tolypocladium inflatum produces a cyclic peptide of 11 amino acids, cyclosporin, it is of great biotechnological importance. Cyclosporin or ciclosporin, as a critical drug in transplantation surgery, shows strong selective immunosuppressive activity in the rejection of the same organ transplanted. It is very useful for the treatment of autoimmune and parasitic diseases It is also a promising drug. Recent work by Weiser et al. Has demonstrated the insect pathogenic activity of cyclosporin A. In addition to T. inflataum, other Tolypocladium species and soil-resident fungi such as Fusarium solani and Neocosmospora vasinfecta are reported to produce small amounts of cyclosporine. In general, insecticidal compounds produced by fungi are lethal to insects. Fungi through the angle layer so that parasitic Kun