药物间的相互作用(DDI)所致的药物不良反应(ADR)日趋严重,致死性的ADR也时有报道。为了减少或避免严重的ADR,临床用药必须综合考虑,权衡利弊,能少用的尽量少用,能不用的尽量不用。此外临床医生必须了解药物是如何吸收、代谢的,必须了解药物的代谢酶,必须了解现在使用的药物是否 The adverse drug reaction (ADR) caused by the drug-drug interaction (DDI) is becoming more and more serious. The fatal ADR has also been reported from time to time. In order to reduce or avoid serious ADR, clinical medication must be considered, weighing the pros and cons, to minimize the use of less, can not use as much as possible. In addition clinicians must understand how the drug is absorbed, metabolized, and must understand the metabolic enzymes of the drug and must understand whether the drug currently in use is