采用体外细胞培养技术 ,观察兔肺泡巨噬细胞死亡率 ,用丙二醛 (MDA)的含量变化、乳酸脱氢酶 (LDH)及超氧化物歧化酶 (SOD)的活性变化来评价来自 1 2个矿床的 6种矿物的1 2种结晶习性的矿物粉尘的细胞毒性 ,探讨其使巨噬细胞受损的机制。结果显示 :沸石、硅灰石无细胞毒性 ,而其他的纤维状及片粒状矿物粉尘则表现出不同程度的细胞毒性 ,说明矿物粉尘的细胞毒性与矿物粉尘的形态有一定关系 ,但主要由矿物粉尘的特性所决定 The death rate of alveolar macrophages in rabbits was observed by cell culture in vitro. The changes of malondialdehyde (MDA) content, the activities of lactate dehydrogenase (LDH) and superoxide dismutase (SOD) A mineral deposit of 12 kinds of crystal habit minerals dust of 6 kinds of minerals in a mineral deposit was explored and its mechanism of macrophage damage was explored. The results showed that: zeolite, wollastonite without cytotoxicity, while other fibrous and granular particulate mineral dust showed varying degrees of cytotoxicity, indicating that the toxicity of mineral dust and the morphology of mineral dust has a certain relationship, but mainly composed of minerals Dust characteristics of the decision